Recombinant Human Anti-IAV HA1 chain Antibody (C05) (CAT#: PABL-223)
Recombinant Human Antibody (C05) is capable of binding to IAV HA1 chain, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA1 chain mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA1 chain mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 EC50 measurements with ELISA for the IgGs reformatted from the selected anti-HA trimer scFvs.
Chen, C., Chiu, Y. K., Yu, C. M., Lee, C. C., Tung, C. P., Tsou, Y. L.,... & Yang, A. S. (2017). High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries. Scientific reports, 7(1), 14455.
Figure 2 IC50 measurements with pseudo virus-based microneutralization assay for the IgGs reformatted from the selected anti-HA trimer scFvs.
Chen, C., Chiu, Y. K., Yu, C. M., Lee, C. C., Tung, C. P., Tsou, Y. L.,... & Yang, A. S. (2017). High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries. Scientific reports, 7(1), 14455.
Specifications
- Immunogen
- Influenza a virus Hemagglutinin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native IAV HA
- Species Reactivity
- IAV
- Clone
- C05
- Applications
- ELISA, Neut, WB, FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- In vivo protection in mice
Animal experiments were performed in accordance with the guidelines of the Mount Sinai School of Medicine and St. Jude Children's Research Hospital Institutional Animal Care and Use Committees (IACUC). All animal experiments were done essentially as described in8. Virus strains used in these studies were A/Memphis/3/2008 (H1N1) and A/Aichi/1/X-31/1968 (H3N2). 5–6 week old BALB/c mice were used for the H1N1 studies and 8-week old DBA/2 mice for the H3N2 studies.
Target
- Alternative Names
- HA; hemagglutinin; haemagglutinin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MHC Tetramer Products for Virology
Single Domain Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-203 | Recombinant Human Anti-IAV HA Antibody (3.1) | WB, ELISA, FuncS | IgG |
| PABL-204 | Recombinant Human Anti-IAV HA Antibody (39.29) | Neut, FuncS | IgG |
| PABL-205 | Recombinant Human Anti-IAV HA Antibody (1957) | WB, Neut, FuncS | IgG |
| PABL-206 | Recombinant Human Anti-IAV HA Antibody (1F1) | WB, ELISA, FuncS | IgG |
| VS-0423-XY3 | Human Anti-HA Recombinant Antibody (clone 019-10117-3C06) | ELISA | Human IgG |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABL-223, RRID: AB_3111640)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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